Abstract: Based on the single factor experiments，the response surface methodology（RSM）was employed to optimize the extractions of polysaccharides from Fuling and its main ingredients were analyzed. The results of optimum extraction conditions were as follow：the extraction temperature 50℃，stress 21.78 MPa，concentration of cosolvent 83.19%. Under these conditions，the average extraction yield was 3.104%. The optimization of Fuling extraction process technology was reasonable and feasible.

Key words: Fuling, supercritical CO2, polysaccharides extraction, response surface

摘要： 茯苓多糖具有抗肿瘤、增加免疫力等多种功能，应用前景广泛，为进一步优化提取工艺，在单因素基础上，利用响应面法确定超临界CO2提取水溶性茯苓多糖的最佳工艺条件，并对其主要成分进行分析。结果表明茯苓的最佳加工工艺萃取温度50℃、萃取压力21.78 MPa、夹带剂浓度83.19%，此条件下茯苓多糖得率为3.104%，表明优选的超临界方法提取水溶性茯苓多糖优于传统方法。

关键词: 茯苓, 超临界CO2, 多糖提取, 响应面