关键词: 鱼, 基因工程疫苗, 免疫, 保护作用

Abstract: Chemicals used for the prevention and control of fish diseases have brought about the deterioration of water quality, excessive drug residues in aquatic products and increased drug resistance of pathogens. With the development of the fish immunology and molecular biological technology, genetically engineered vaccines for fish diseases have been given considerable attention. This paper systematically summarized the background, significance, types and research status of fish genetic engineered vaccine, clarified challenges and proposed some suggestions for further development, which would provide reference for the development and application of the fish vaccines in the future.

Key words: fish, genetically engineered vaccine, immunity, protective effect