关键词: 代谢组学, 全基因组关联分析, mGWAS, 进展

Abstract: Plants have the ability to create diverse compounds known as metabolites, these compounds not only mediate plant growth and development, but also play important roles in defense mechanisms of plant. In addition, many metabolites are desirable as nutrition and medicine for humans. Metabolomics enables comprehensive high throughput quantification of metabolites, which is valuable for both phenotype and genes. Recent researches showed that GWAS coupled with metabolome analysis (mGWAS) exhibited great potential to dissect the genetic and biochemical bases of metabolome diversity. This paper reviewed mGWAS as a powerful tool for exploring the basis of physiology and biology in plant productivity and quality, the metabolic and molecular mechanisms of metabolites in regulating plant growth, development and stress responses. It summarized current advance of plant physiology and biology in metabolites and metabolic networks. In addition, the application of mGWAS in crop improvement and its future prospect were also discussed.

Key words: metabolomics, genome-wide association studies, mGWAS, advance