Abstract:

A sensitive LCMS/MS method for simultaneously analyzing atrazine and its 6 metabolites in cattle drinking water was established. The samples were enriched and purified by MCX solidphase column, determined by LCMS/MS, and quantified by outer standard. The results showed that the linear range spanned from 0.4 to 100 μg/L with correlation index r2 greated than 0.99. At the concentration range of 0.03～3 μg/L, except the recovery of desisopropyl2hydroxy was 6417%, others were 71.31%~116.67% with relative standard deviations ranging from 097％ to 12.03%. The limits of detection (LOD) of 7 substances analyses were 0.1 μg/L. Those indicated the method was rapid, costeffective and suitable for water sample analysis.

Key words: atrazine, HPLCMS, drinking water, metabolites

摘要：

建立了高效液相色谱质谱联用检测奶牛饮用水中莠去津及其6种代谢物残留的同步分析方法。利用MCX固相萃取柱富集净化，采用液相色谱-质谱串联进行测定，外标法定量。结果表明莠去津及其代谢物在0.4~100 μg/L范围内线性良好，标准曲线相关系数r2均大于0.99。在0.03～3 μg/L浓度范围内，平均加标回收率除脱异丙基羟基莠去津的较低(64.17%)外，其他目标物的回收率在71.31％~116.67％之间，相对标准偏差为0.97％~12.03％。7种目标物的检出限为0.01 μg/L，方法的灵敏度较高，且简便、快速。

关键词: 莠去津;液相色谱质谱联用;饮用水;代谢物